Repo Dosen ULM

The Quality of Rat Brain Spatial Memory and Expression of Peroxisome Proliferator Activated Receptor (PPAR) Which Fed with Seluang (Rasbora spp.)

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dc.contributor.author Yunanto, Ari
dc.contributor.author Dwi Sanyoto, Didik
dc.contributor.author Syahadatina Noor, Meitria
dc.contributor.author Kustiyah, Ika
dc.contributor.author Triawanti, Triawanti
dc.date.accessioned 2020-09-01T02:03:19Z
dc.date.available 2020-09-01T02:03:19Z
dc.date.issued 2015-12-02
dc.identifier.other DOI : 10.18178/jolst.3.2.43-47
dc.identifier.uri https://repo-dosen.ulm.ac.id//handle/123456789/17718
dc.description.abstract Abstract—Seluang fish (Rasbora spp.) besides contain high protein also contain an essential fatty acids (PUFA), which can increase intelligence. The objective of this research was to prove that Seluang fish is one of the nutrient source to increase the spatial memory and expression of PPAR brain tissue by using Rattus norvegicus as a model. Rats were divided into 3 groups: control group were fed standard (C), Treatment Group 1 were fed low-protein and fat (P1), Group Treatment 2 (P2) were fed standard with Seluang Formula, for 8 weeks. The first phase was to testing spatial memory using the Morris Water Maze. The second phase, was the making brain tissue’s slide preparation, immunohistochemical stained, calculated the percentage of PPARá and PPARã expression. The data analysed using ANOVA and Kruskal Wallis test with a 95% confidence level. The first phase results showed the percentage of period time in the target area for the P2 group is the highest compared to the C and P1 group, respectively 33.52%; 29.9%; and 23.15% (p = 0.021). On PPARá and PPARã examination showed the average percentage of PPARá neurons expression in group P2 is higher than the C and P1 group, respectively 18.5%, 3.75% and 2.5% (p = 0.002) Average percentage of total PPARã neuronan cells expression in P2 group also higher than the C and P1 group, respectively 35.41%, 6.25% and 5.83% (p = 0.001). The study shows that rats fed with Seluang Fish Formula able to improved the brain tissue’s spatial memory and PPAR expression. en_US
dc.description.sponsorship DIKTI en_US
dc.language.iso en en_US
dc.publisher Journal of Life Sciences and Technologies en_US
dc.subject spatial memory en_US
dc.subject PPAR expression en_US
dc.subject Terms—seluang fish (Rasbora Spp en_US
dc.title The Quality of Rat Brain Spatial Memory and Expression of Peroxisome Proliferator Activated Receptor (PPAR) Which Fed with Seluang (Rasbora spp.) en_US
dc.type Article en_US


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