Reduction of Oxidative Stress by Seluang Fish (Rasbora spp.) in Brain of Malnourished Rats (Rattus norvegicus)

Abstract

Abstract—Malnutrition children have lower intelligence due to brain cells damage caused by oxidative stress. Seluang (Rasbora spp.) has the potential te reduce this problem. This study aimed to analyze the correlation between hydrogen peroxide (H2O2) levels with malondialdehyde (MDA) levels in the brain of malnourished rats after administration of seluang. This study used a posttest only with control group design. 30 white rats (Rattus norvegicus) made into malnutrition and divided into three groups, M: malnutrition group, P1: malnourished rats fed standard diet, P2: malnourished rats fed seluang for 4 weeks. The results showed that malnourished rats had the highest levels of H2O2. ANOVA statistical tests showed a significant differences between H2O2 levels (p = 0.001) and MDA levels (p = 0.001) among malnutrition group with the other groups Pearson correlation test results concluded that there was a correlation H2O2 levels with MDA levels (p = 0.001, r = 0.684) as indicated by decrease of H2O2 levels followed by decrease in MDA levels. This study showed a correlation between H2O2 levels and MDA levels in the of malnourished rat brain fed seluang. Thus seluang can improve the condition of oxidative stress in malnourished rat brain.