Bodyweight and body length of foetus in endothelial dysfunction model pregnant mus musculus as preeclampsia induction which was given mild regular exercise

Abstract

Preeclampsia is condition with diastol blood pressure become ≥ 90 mmHg and proteinuria in gestation more than 20 weeks. Maternal mortality in Indonesia was caused by preeclampsia as the number 2 of causes. Preeclampsia is signed by endothelial dysfunction. Prevention of preeclampsia had not been developed yet. Exercise is activity which can induce endogen anti in􀏐lammation and antioxidant. So, it can be used to prevent the same process in preeclampsia. The goal of this research was analyzing the difference of bodyweight and body length in endothelial dysfunction pregnant Mus musculus which was given mild regular exercise and whithout exercise. This research was true experimental with post test only with control group design, consited of 2 steps. Step 1 to know the dose of anti QA2, and step 2 to know the effect of mild regular exercise to bodyweight and bodylength of foetus. Step 2 consisted of 4 groups (K1 for control normal pregnant, K2 for injected anti QA2 as endothelial dysfunction model pregnant, K3 for injected anti QA2 as endothelial dysfunction model pregnant with mild regular exercise since early pregnant, K4 for injected anti QA2 as endothelial dysfunction model pregnant with mild regular exercise since 1 week before pregnant). The number of Mus musculus were 6/group based on Federer formula. Determination of anti QA2 dose to induce endothelial dysfunction was done by using some doses and examining vasoconstriction of vessel in uterus by HE examanation. The dose that caused optimal vasoconstriction was 50 ng. The result showed there was no signi􀏐icant different of bodyweight among all groups (p = 0.432), but bodyweight in K4 (0.9102 grams) was more than K2 (0.8388 grams). There was no signi􀏐icant different of bodylength also among all of groups (p =0.662), but bodylength in K4 (2.1897 cm) was longer than K2 (2.0939 cm). The conclusion was there was no signi􀏐icant differences of bodyweight and body length in endothelial dysfunction pregnant Mus musculus as preeclampsia induction which was given mild regular exercise and whithout exercise.