The effect of salbutamol sulfate exposures on the amount of fluoride ion, calcium ion and aluminum ion release from GIC

Abstract

Background: Asthma is a chronic inflammatory disease of the respiratory tract. The most commonly used for asthma treatment is the β2-agonist salbutamol sulfate. Salbutamol sulfate has a low pH so it can affect the restoration material. One of the restoration materials that is still widely used by dentists and continues to be developed is Glass Ionomer Cement (GIC). In a low pH environment, GIC can release fluoride ions, calcium ions and aluminum ions. Objective: To analyze the effect of salbutamol sulfate exposures on the amount of fluoride ions, calcium ions and aluminum ions release from GIC. Method: This study used true experimental and post-test only with control group design that used 21 GIC samples with diameter of 5 mm with 2 mm thickness divided into 3 groups, i.e. the group exposed to 400 μg, 800 μg salbutamol sulfate and artificial saliva as control group with repeated treatments every 24 hours for 7 days. The measurement of the amount of fluoride ions release by using a pH meter, meanwhile calcium ions and aluminum ions release using the titration method. Results: One Way Anova and Post Hoc Bonferroni showed significant differences in the amount of fluoride ions release in 400 μg (3.165 ± 0.415 ppm), 800 μg (3.879 ± 0.703 ppm) and artificial saliva as control group (2.333 ± 0.412 ppm), the amount of calcium ions release in 400 μg (6.943 ± 0.836 mg/gram), 800 μg (7.114 ± 0.871 mg/gram) and the artificial saliva as control group (5.986 ± 0.430 mg/gram) and the amount of aluminum ions release in 400 μg (0,197 ± 0,089 mg), 800 μg (0,730 ± 0,034 mg) and the artificial saliva as control group (0,029 ± 0,023 mg). Conclusion: There is an effect of salbutamol sulfate exposures on the amount of fluoride ions, calcium ions and aluminum ions release from GIC. Keywords: Glass Ionomer Cement (GIC), Salbutamol sulfate, The amount of aluminum ions release, The amount of calcium ions release, The amount of fluoride ions release.