Effect of Karamunting Fruit Juice (Melastoma Malabathricum L.) to Advanced Glycation End-Products (AGEs) and Lipid Profile as Advanced Complications of Diabetes Mellitus

Abstract

Hyperglycemia as a result of Diabetes Mellitus (DM) could lead to an increase in free radicals that lead to oxidative stress, it will end with the formation of Advanced Glycation Ends Products (AGEs) and dyslipidemia which contributed in the complications of diabetes. Karamunting is believed and consumed by local society for treat DM, unfortunately currently there is no scientific data to support it. The purpose of this study was to determined the potential Karamunting fruit plants that are typical South Kalimantan by calculating the levels of methyl glyoxal, carbonyl, LDL, HDL, total cholesterol and triglycerides. This study is consists of six groups each of six male rats. Then do the induction streptozosin in Groups 2-5 mice at a dose of 40 mg kg–1 intraperitoneally, followed by treatment in the form of: Group 1 and 2 are given distilled water; Group 3 was given metformin (anti-hyperglycemic medications) 10 mg kg–1; Group 4-6 granted Karamunting fruit juice with successive doses 0:01 mg g–1; 0.1 mg g–1; 1 mg g–1. AGEs results showed that there were a significant reduction of carbonyl levels in fruit juices Karamunting within three doses (0.01, 0.1 and 1 mg g–1), i.e., from 3.273 into 2.598; 2.485; 2.470 (p<0.005) and a significant decrease methyl glyoxal levels, i.e., from 0.039 into 0.021; 0.018; 0.016 (p<0.005). On result of the levels of LDL, HDL, triglycerides and total cholesterol showed a non-significant results (p>0.05). It can be concluded that it could lower the level of AGEs compound but not lipid profile significantly. There were no significant differences between the three different doses of metformin and Karamunting (p>0.05) indicating that the Karamunting has the same efficacy with metformin.