| dc.creator |
Sutomo, Sutomo |
|
| dc.date |
2013-09 |
|
| dc.date.accessioned |
2020-06-15T04:04:47Z |
|
| dc.date.available |
2020-06-15T04:04:47Z |
|
| dc.identifier |
http://eprints.ulm.ac.id/8667/1/9.%20Jurnal_Sutomo_2013.1.pdf |
|
| dc.identifier |
Sutomo, Sutomo (2013) AKTIVITAS ANTIINFLAMASI EKSTRAK METANOLIK BUAH MANGGA KASTURI (Mangifera casturi) MELALUI PENGHAMBATAN MIGRASI LEUKOSIT PADA MENCIT YANG DIINDUKSI THIOGLIKOLAT. AKTIVITAS ANTIINFLAMASI EKSTRAK METANOLIK BUAH MANGGA KASTURI (Mangifera casturi) MELALUI PENGHAMBATAN MIGRASI LEUKOSIT PADA MENCIT YANG DIINDUKSI THIOGLIKOLAT, 18 (3). ISSN 1410-5918 |
|
| dc.identifier.uri |
https://repo-dosen.ulm.ac.id//handle/123456789/13832 |
|
| dc.description |
Kasturi (Mangifera casturi) is a plant originally from Kalimantan, mainly in South Kalimantan.
Although there is no report regarding the usage of the fruit in traditional healings, current research
demonstrate that methanolic extract of Mangifera casturi fruit demonstrated high antioxidant activity. As
oxidant plays crucial role in inflammatory related diseases, we investigate the antiinflammatory effect of
Mangifera casturi fruit methanolic extract. To assess the antiinflammatory activity, we used thioglycollateinduced
leukocyte migration in mice. Male balb/c mice were pretreated (i.p) with Mangifera casturi fruit
methanolic extract followed by thioglikolat (i.p) to induce leukocyte migration. After 4,5 hours, the mice were
sacrificed and the number of leukocytes were counted using hemocytometer under light microscope. Our
experiment indicates that Mangifera casturi fruit methanolic extract significantly exhibited
antiinflammatory activity by inhibiting the migration of leukocytes induced by thioglycollate. However, the
activity of the extracts was lower than the positive control, indomethacin. Further purification was required
to obtain the active compound with the activity comparable to indomethacin. Thin layer chromatography
(TLC) analysis demonstrates that the methanolic extract of Mangifera casturi fruit contains terpenoid and
phenolic compounds.
Key word: Mangifera casturi, leukocyte migration, antiinflammation |
|
| dc.format |
text |
|
| dc.publisher |
Traditional Medicine Journal |
|
| dc.relation |
http://eprints.ulm.ac.id/8667/ |
|
| dc.subject |
RS Pharmacy and materia medica |
|
| dc.title |
AKTIVITAS ANTIINFLAMASI EKSTRAK METANOLIK BUAH MANGGA KASTURI (Mangifera casturi) MELALUI PENGHAMBATAN MIGRASI LEUKOSIT PADA MENCIT YANG DIINDUKSI THIOGLIKOLAT |
|
| dc.type |
Article |
|
| dc.type |
PeerReviewed |
|