| dc.creator |
Sutomo, Sutomo |
|
| dc.date |
2018-03 |
|
| dc.date.accessioned |
2020-06-15T04:04:46Z |
|
| dc.date.available |
2020-06-15T04:04:46Z |
|
| dc.identifier |
http://eprints.ulm.ac.id/8644/1/5.%20Journal_Sutomo_2018.pdf |
|
| dc.identifier |
Sutomo, Sutomo (2018) Chemical Structure Optimization of Lupeol As ER-A and HER2 Inhibitor. Chemical Structure Optimization of Lupeol As ER-A and HER2 Inhibitor, 11 (298). ISSN 2455-3891 |
|
| dc.identifier.uri |
https://repo-dosen.ulm.ac.id//handle/123456789/13824 |
|
| dc.description |
Objectives: Lupeol, a triterpenoid isolated from Kasturi (Mangifera casturi) fruit has been known for having several pharmacological activities, including anticancer properties. Lupeol showed antiproliferative activity toward many cancer cells line including breast cancer. Lupeol showed promising potency as both ER-α and HER2 inhibitors, although still lower than known ER-α and HER2 Inhibitors. Chemical structure optimization of lupeol was predicted could increase the affinity of lupeol derivatives against ER-α and HER2. This study aims to determine lupeol derivative with the highest affinity against ER-α and HER2. |
|
| dc.format |
text |
|
| dc.publisher |
sian J Pharm Clin Res, Vol 11, Issue 6, 2018, 298-303 |
|
| dc.relation |
http://eprints.ulm.ac.id/8644/ |
|
| dc.subject |
RS Pharmacy and materia medica |
|
| dc.title |
Chemical Structure Optimization of Lupeol As ER-A and HER2 Inhibitor |
|
| dc.type |
Article |
|
| dc.type |
PeerReviewed |
|