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In Vitro Antiplasmodial Activity of Ethanol Extract of Manuran (Coptosapelta Tomentosa Valeton Ex K. Heyne) Roots

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dc.creator Sutomo, Sutomo
dc.date 2017-01
dc.date.accessioned 2020-06-15T04:04:46Z
dc.date.available 2020-06-15T04:04:46Z
dc.identifier http://eprints.ulm.ac.id/8637/1/4.%20Journal_RJPBCS%20Arnida%20Sutomo_2017.2.pdf
dc.identifier Sutomo, Sutomo (2017) In Vitro Antiplasmodial Activity of Ethanol Extract of Manuran (Coptosapelta Tomentosa Valeton Ex K. Heyne) Roots. In Vitro Antiplasmodial Activity of Ethanol Extract of Manuran (Coptosapelta Tomentosa Valeton Ex K. Heyne) Roots. ISSN 0975-8585
dc.identifier.uri https://repo-dosen.ulm.ac.id//handle/123456789/13822
dc.description The efforts to find alternative antimalarial medicine have not essentially solved the problem of malaria control because of the presence of medication resistance. The Plasmodium resistance to antimalarial medicine is resulted from malaria treatment failure. Therefore, the availability of new antimalarial medicine is urgently needed to overcome the resistance problems. Coptosapelta tomentosa is empirically used by people in Kotabaru South Kalimantan as part of the treatment for Malaria. The aim of this research was to determine IC50 value of in vitro antiplasmodial activities from ethanol extract of C. tomentosa roots. Coarse powder of C. tomentosa roots was extracted using ethanol 96% by maceration method. An in vitro antiplasmodial activity test was carried out by using Candle Jar method. The doses of administration of ethanolic extract of C. tomentosa roots were at 500; 250; 50; 25; 5; dan 0.5 μg/mL concentration. The results of the study included parasitemia percentage, P. falciparum growth inhibition percentage and IC50 value. The IC50 value of the ethanol extract of C. tomentosa roots was 2.46 μg/mL. The in vitro antiplasmodial activities of ethanol extracts of C. tomentosa roots were categorized to be very active. Keywords: Captosapelta tomentosa; Manuran; in vitro antiplasmodial activity; Borneo; Kalimantan
dc.format text
dc.publisher RJPBCS Research Journal of Pharmaceutical, Biological and Chemical Sciences
dc.relation http://eprints.ulm.ac.id/8637/
dc.subject RS Pharmacy and materia medica
dc.title In Vitro Antiplasmodial Activity of Ethanol Extract of Manuran (Coptosapelta Tomentosa Valeton Ex K. Heyne) Roots
dc.type Article
dc.type PeerReviewed


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