| dc.creator |
Illiandri, Oski |
|
| dc.date.accessioned |
2020-06-15T04:02:19Z |
|
| dc.date.available |
2020-06-15T04:02:19Z |
|
| dc.identifier |
http://eprints.ulm.ac.id/6059/1/40713-Article_Text-143775-1-10-20190406.pdf |
|
| dc.identifier |
Illiandri, Oski The role of 4-pba on tnf-alpha related apoptosis on human vein endothelial cells. The role of 4-pba on tnf-alpha related apoptosis on human vein endothelial cells. |
|
| dc.identifier.uri |
https://repo-dosen.ulm.ac.id//handle/123456789/12633 |
|
| dc.description |
Tumor Necrotizing Factor-alpha (TNF-α) has been well-known as a potent
pro-inflamatory cytokine involved in many degenerative disease. One of its primary
target organ-damaged was endothelial cells which will lead to its endoplasmic
reticulum stress (ERS) and induced its apoptosis. Endothelial cell apoptosis will lead
high implication in many disease pathomechanism of many degenerative disease.
Some study report ERS inhibitor 4-Phenyl Butyric Acid (4-PBA) properties to inhibit
inflammation process in endothelial cells. However, wether 4-PBA can decrease
apoptosis level in inflamation of endothelial cells is still poorly understood.
Objective. This study to answer whether 4-PBA can decrease apoptosis triggered by
inflammatory reactions mediated by TNFα. Methods: This study is an exploratory
study laboratory in vitro using cell culture Human Umbilical Vein Endothelial Cells
(HUVEC) apoptotic count cells with the design of post test only control group
consisting of three treatment groups with doses of 4-PBA 1 nM / mL, 2 nM /mL, and
3 nM /m L. Results. Administration 4-PBA in cultured HUVEC derived endothelial
cells significantly decrease apoptosis at any dose of PBA but no dose dependently (p
<0.05). Conclusion: Based on the results that has been done, it can be concluded that
4-PBA can reduce levels of endothelial cells apoptosis which were exposed to
proinflamatory cytokine TNF-α. Further research need to elucidated 4-PBA
mechanism to inhibit endothelial apoptosis. |
|
| dc.format |
text |
|
| dc.relation |
https://www.banglajol.info/index.php/BJMS/article/view/40713 |
|
| dc.relation |
http://eprints.ulm.ac.id/6059/ |
|
| dc.subject |
R Medicine (General) |
|
| dc.title |
The role of 4-pba on tnf-alpha related apoptosis on human vein endothelial cells |
|
| dc.type |
Article |
|
| dc.type |
PeerReviewed |
|