| dc.creator |
Arnida, Arnida |
|
| dc.date.accessioned |
2020-06-15T04:02:13Z |
|
| dc.date.available |
2020-06-15T04:02:13Z |
|
| dc.identifier |
http://eprints.ulm.ac.id/6034/2/Abstract_AKTIVITAS_PENGHAMBATA_N_POLIMERISASI_HEM_DARI_FRAKSI_ETIL_ASETAT_DAUN_MANURAN.pdf |
|
| dc.identifier |
Arnida, Arnida AKTIVITAS PENGHAMBATA N POLIMERISASI HEM DARI FRAKSI ETIL ASETAT DAUN MANURAN,. Jurnal FITOFARMAKA. |
|
| dc.identifier.uri |
https://repo-dosen.ulm.ac.id//handle/123456789/12580 |
|
| dc.description |
Malaria is a serious disease caused by Plasmodium parasites and is transmitted by the
salivary glands of female Anopheles mosquito. The manuran (Coptosapelta tomentosa
Valeton ex K.Heyne) is empirically used as a malarial treatment. The study aimed to
determine the IC50 value of ethyl acetate fraction and the coumpounds contained on the C.
tomentosa Valeton ex K. Heyne leaf ethyl acetat fraction. The identification of chemical
composition used tube test method. The inhibitory activity of heme polymerization in vitro did
by Basillico modified method. The identification of chemical contents on the ethyl acetate
fraction of C. tomentosa leaf Valeton ex K. Heyne showed positive results containing
flavonoid, tannin, saponin, terpenoid, and anthraquinone. The average percentage heme
polymerization inhibition of C. tomentosa valeton ex K. Heyne leaf ethyl acetate fraction
respectively from large to small concentrations of 97.94; 96.94; 95.01; 91.63; 86.19; 76.12;
and 44.83 %. Result of probit analysis, that it has HPIA IC50 value of 0.252±0.009 mg/mL
and chloroquine diphosphate was 0.214±0.012 mg/mL. The independent sample T-test
showed that there was significant difference between IC50 value of them. The ethyl acetate
fraction of C. tomentosa leaf Valeton ex K. Heyne has heme polymerization inhibition
activity. |
|
| dc.format |
text |
|
| dc.relation |
http://jurnal.farmasi.umi.ac.id/index.php/fitofarmakaindo/article/view/459 |
|
| dc.relation |
http://eprints.ulm.ac.id/6034/ |
|
| dc.subject |
R Medicine (General) |
|
| dc.title |
AKTIVITAS PENGHAMBATA N POLIMERISASI HEM DARI FRAKSI
ETIL ASETAT DAUN MANURAN, |
|
| dc.type |
Article |
|
| dc.type |
PeerReviewed |
|