| dc.creator |
NUGROHO, AGUNG |
|
| dc.date.accessioned |
2020-06-15T03:57:37Z |
|
| dc.date.available |
2020-06-15T03:57:37Z |
|
| dc.identifier |
http://eprints.ulm.ac.id/1538/1/APJTB-Carica_papaya-final.pdf |
|
| dc.identifier |
NUGROHO, AGUNG Identification and quantification of flavonoids in Carica papaya leaf and peroxynitrite- scavenging activity. Identification and quantification of flavonoids in Carica papaya leaf and peroxynitrite- scavenging activity. |
|
| dc.identifier.uri |
https://repo-dosen.ulm.ac.id//handle/123456789/10136 |
|
| dc.description |
Objective: To characterize the types, contents, and peroxynitrite-scavenging activities of
flavonoids in the leaf of Carica papaya (C. papaya).
Methods: Chromatographic and spectroscopic techniques along with high performance
liquid chromatography quantitative analysis and peroxynitrite-scavenging assay were
performed to isolate and quantify flavonoid compounds in the flavonoid-rich fraction
(BuOH fraction) derived from MeOH extract of C. papaya leaves and evaluate their
peroxynitrite-scavenging activities.
Results: Seven flavonoids were isolated from the leaves of C. papaya, including quercetin
3-(2G-rhamnosylrutinoside), kaempferol 3-(2G-rhamnosylrutinoside), quercetin 3-
rutinoside, myricetin 3-rhamnoside, kaempferol 3-rutinoside, quercetin, and kaempferol.
All of the substances exhibited potent activities on peroxynitrite scavenging
(IC50 � 4.15 mmol/L), which were stronger than the positive control, L-penicillamine
(6.90 mmol/L). The content of kaempferol 3-(2G-rhamnosylrutinoside) was significantly
higher than other identified compounds (123.18 mg/g BuOH fraction and 7.23 mg/g
MeOH extract).
Conclusions: The results of the present study demonstrate the potent antioxidant flavonoids
of C. papaya leaf, with kaempferol 3-(2G-rhamnosylrutinoside) as the major
one. |
|
| dc.format |
text |
|
| dc.relation |
http://www.sciencedirect.com/science/article/pii/S2221169116306402 |
|
| dc.relation |
http://eprints.ulm.ac.id/1538/ |
|
| dc.subject |
AI Indexes (General) |
|
| dc.title |
Identification and quantification of flavonoids in Carica papaya leaf and peroxynitrite- scavenging activity |
|
| dc.type |
Article |
|
| dc.type |
PeerReviewed |
|