| dc.creator |
Nurlely, Nurlely |
|
| dc.date.accessioned |
2020-06-15T03:57:34Z |
|
| dc.date.available |
2020-06-15T03:57:34Z |
|
| dc.identifier |
http://eprints.ulm.ac.id/1525/1/Nurlely_THE_ABSTRACT_TEMPLATE_FOR_2nd_ISHHAS_2017_%28revised%29.pdf |
|
| dc.identifier |
Nurlely, Nurlely Antioxidant and Hypoglycemic Effects of Aquilaria microcarpa Baill in Alloxan Induced Diabetic Rats. Antioxidant and Hypoglycemic Effects of Aquilaria microcarpa Baill in Alloxan Induced Diabetic Rats. |
|
| dc.identifier.uri |
https://repo-dosen.ulm.ac.id//handle/123456789/10108 |
|
| dc.description |
ABSTRACT
Background:
Oxidative stress may induce some pathological conditions like diabetes mellitus
characterized by the elevated blood glucose level. The present study was carried out to
determine the total flavonoids and phenolics contents, antioxidant and hypoglycemic
effects of methanol, ethyl acetate extracts and decoction of Aquilaria microcarpa Baill
leaves
Methods :
Extracts were performed using percolation method. Total flavonoids and phenolics
contents were analyzed by the Folin–Ciocalteu colorimetric and aluminium trichloride
assays respectively while antioxidant effect was determined using the 2,2-diphenyl-1-
picrylhydrazyl radical scavenging assay. Hypoglycemic effect was evaluated in alloxan
induced diabetic rats for 14 days and measured by mainly estimating pre– and postprandial
blood glucose and glycogen liver levels.
Results
Ethyl acetate extract revealed the highest total flavonoid content followed by methanol
extract and decoction [(475.08±3.4) , (117.24±0.5) and (82.38±0.5) mg quercetin
equivalent/1 g extract respectively]. While methanol extract revealed the highest total
phenols content followed by ethyl acetate extract and decoction [(534.43±0.47),
(62.92±0.46) and (0.913±0.00) mg gallic acid equivalent/1 mg extract respectively).
Antioxidant capacity (IC50 value) for methanol extract, ethyl acetate extract and decoction
were 15.59, 58.33 and 24.52 ppm respectively. All extracts and decoction significantly
(p<0.05) decreased pre– and postprandial blood glucose levels and increased glycogen
liver level.
Conclusions :
Therefore, it can be concluded that methanol extract, ethyl acetate extract and decoction
possess antioxidant and hypoglygemic effects.
Keywords: antioxidant, hypoglycemic effect, Aquilaria microcarpa Baill |
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| dc.format |
text |
|
| dc.relation |
http://ishhas.fkunissula.ac.id/ |
|
| dc.relation |
http://eprints.ulm.ac.id/1525/ |
|
| dc.subject |
AI Indexes (General) |
|
| dc.title |
Antioxidant and Hypoglycemic Effects of Aquilaria microcarpa Baill in Alloxan Induced Diabetic Rats |
|
| dc.type |
Article |
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| dc.type |
PeerReviewed |
|